由于 Aminex 系列 HPLC 色谱柱在糖类和有机酸检测中的出色应用，因此相关专家随即将其应用扩展到了临床研究领域。

通过对包括唾液、尿液、血液血浆以及其他生物液体中的各种有机酸以及单寡糖的成分检测，可以对诸如代谢缺陷病、糖尿病、肿瘤以及其他类病症、微生物群落情况进行监测和分析，在很多情况下可以作为临床诊断的有效指标之一。

此外，对于血液以及血浆的质量控制，临床试用的药物的制剂包括注射液、口服液等 Aminex 也有着出色的应用。

以下是 Aminex 色谱柱在临床研究领域的应用文献汇总。

临床研究领域

1.   细菌性阴道病有机酸检测分析

Stanek, R., Gain, R. E., Glover, D. D. and Larsen, B., Biomed. Chrom., 6,231-235 (1992).High Performance Ion Exclusion Chromatographic Characterization of the Vaginal Organic Acids in Women with Bacterial Vaginosis.

2.  口服液中碳水化合物甜味剂和有机酸的定量

Linke, H. A. B. and Moss, S. J., Z. Ernaehrungswiss., 31, 147-154 (1992).Quantitation of Carbohydrate Sweeteners and Organic Acids in Human Oral Fluid Using HPLC Analysis.

3.  测定生物体液中的胰岛素

Ruo, T. I., Wang, Z., Dordal, M. S. and Atkinson, Jr., A. J., Clinica Chimica Acta, 204, 217-222 (1991).

Assay of Insulin in Biological Fluids by HPLC with Pulsed Amperometric Detection.

4.  保存的血浆中的抗坏血酸和脱氢抗坏血酸 c 测量

Margolis, S. A., Paule, R. C. and Ziegler, R. G., Clin. Chem., 36, 1750-1755 (1990).

Ascorbic and Dehydroascorbic Acids Measured in Plasma Preserved with Dithiothreitol or Metaphosphoric Acid.

5.  快速分析血浆和尿的有机酸

Chong, W. K., Mills, G. A., Weavind, G. P. and Walker, V., J. Chrom., 487,147-153 (1989).

HPLC Method for the Rapid Profiling of Plasma and Urinary Organic Acids.

6.  测定血液中柠檬酸循环中间体

aas, R. H., Breuer, J. and Hammen, M., J. Chrom., 425, 47-57 (1988).HPLC Measurement of Selected Blood Citric Acid Cycle Intermediates.

7.  脑乳酸中毒：丙酮酸代谢缺陷导致的脑损伤以及全身酸中毒

Brown, G. K., Haan, E. A., Kirby, D. M., Scholem, R. D., Wraith, J. E.,Rogers, J. G. and Danks, D. M., Eur. J. Pediatr., 147, 10-14 (1988).“Cerebral” Lactic Acidosis: Defects in Pyruvate Metabolism with Profound Brain Damage and Minimal Systemic Acidosis.

8.  糖尿病患者血浆中的3-羟基-3-甲基戊二酸、己二酸和 2-氧代戊二酸测定

Lippe, G., Trevisan, R., Nosadini, R., Fabris, R. and Deana, R., Clin. Biochem.,20, 275-279 (1987).3-Hydroxy-3-Methylglutaric, Adipic, and 2-Oxoglutaric Acids Measured by HPLC in the Plasma from Diabetic Patients.

9.  过敏源提取物以及诊断抗原的研究

Del Grosso, A. V. and May, J. C., J. Assoc. Off. Anal. Chem., 70, 825-828(1987).Gas Chromatographic, Liquid Chromatographic and Titrimetric Procedures for Determination of Glycerin in Allergenic Extracts and Diagnostic Antigens:Comparative Study.

10.  唾液酸的检测

Mononen, I., J. Chrom., 381, 219-224 (1986). Detection of Sialuria by Cation-Exchange HPLC.

11.  血液中有机酸的检测

Halls, H. J. and Teubner, J. K., Clin. Chem., 32, 1979 (1986).

Liquid-Chromatographic Determination of Organic Acids in Plasma.

12.  生理液中的羧酸：3-羟基-3-甲基戊二酸酸尿症

Buchanan, D. N. and Thoene, J. G., Clin. Chem., 32, 169-171 (1986).Photodiode Array Detection for Liquid Chromatographic Profiling of Carboxylic Acids in Physiological Fluids: 3-Hydroxy-3-Methylglutaric Aciduria.

12.  生理液中的羧酸：3-羟基-3-甲基戊二酸酸尿症

Buchanan, D. N. and Thoene, J. G., Clin. Chem., 32, 169-171 (1986).Photodiode Array Detection for Liquid Chromatographic Profiling of Carboxylic Acids in Physiological Fluids: 3-Hydroxy-3-Methylglutaric Aciduria.

12.  生理液中的羧酸：3-羟基-3-甲基戊二酸酸尿症

Buchanan, D. N. and Thoene, J. G., Clin. Chem., 32, 169-171 (1986).Photodiode Array Detection for Liquid Chromatographic Profiling of Carboxylic Acids in Physiological Fluids: 3-Hydroxy-3-Methylglutaric Aciduria.

13.  新生儿有机酸尿症的检测

Allen, K. R., Khan, R. and Watson, D., Clin. Chem., 31, 561-563 (1985).Use of a Diode Array Detector in Investigation of Neonatal Organic Aciduria.

14.  Milrinone 注射液以及口服液中的乳酸测定

Wilson, T.D., J. Liq. Chrom., 8, 1629-1650 (1985).

HPLC Determination of Lactic Acid in Milrinone Injection and Oral Solution Using Ion-Exchange Sample Preparation Methods.

15. 碳水化合物，有机酸，糖醇的 HPLC 分析

Oefner, P., Bonn, G. and Bartsch, G., J. Liq. Chrom., 8, 1009-1023 (1985). Ultrafiltration and HPLC Analysis of Seminal Carbohydrates, Organic Acids and Sugar Alcohols.

16.  HPLC 快速分析血浆中的有机酸

Daish, P. and Leonard, J. V., Clinica Chimica Acta, 146, 87-91 (1985).Rapid Profiling of Plasma Organic Acids by HPLC.

17.  有机酸紊乱的筛查

Bennett, M. J. and Bradey, C. E., Clin. Chem., 30, 542-546 (1984).Simpler Liquid Chromatographic Screening for Organic Acid Disorders.

18.  HPLC 检测尿中的寡糖来进行 GM1 神经节苷脂的贮积症诊断

Warner, T. G., Robertson, A. D. and O’Brien, J. S., Clin. Chem. Acta, 127, 313-326 (1983).Diagnosis of GM1 Gangliosidosis Based on detection of Urinary Oligosaccharides with HPLC.

19.  双柱法进行尿的有机酸分析

Buchanan, D. N. and Thoene, J. G., Anal. Biochem., 124, 108-116 (1982).Dual-Column HPLC Urinary Organic Acid Profiling.

20.  红细胞的D-葡萄糖测定

Wong, S. H., Kalache, G. and Morse, E. E., J. Liq. Chrom., 4, 1831-1845 (1981).HPLC Assay of D-Glucose in Erythrocytes.

21.  HPLC 法进行尿有机酸分析

Buchanan, D. N. and Thoene, J. G., J. Liq. Chrom., 4, 1587-1600 (1981).HPLC Urinary Organic Acid Profiling: Role of the Ultraviolet andAmperometric Detectors.

22.  a- 酮羧酸的检测

Buchanan, D. N. and Thoene, J. G., J. Liq. Chrom., 4, 1219-1224 (1981).Analysis of Alpha-Ketocarboxylic Acids by Ion Exchange HPLC with UV andAmperometric Detection.

23.  恶性黑色素瘤和乳腺癌中 N- 乙酰神经氨酸的 HPLC 定量。

Silver, H. K. B. and Karim, K. A., J. Chrom., 224, 381-388 (1981).HPLC Quantitation of N-Acetylneuraminic Acid in Malignant Melanoma and Breast Carcinoma.

24.  HPLC 和光学活测定尿液中的碳水化合物

Kuo, J. C. and Yeung, E. S., J. Chrom., 223, 321-329 (1981).Determination of Carbohydrates in Urine by HPLC and Optical Activity Detection.